X. Edward Guo

STANLEY DICKER PROFESSOR OF BIOMEDICAL ENGINEERING; CHAIR, DEPARTMENT OF BIOMEDICAL ENGINEERING

351 Engineering Terrace
Mail Code 8904

Tel(212) 854-6196
Fax(212) 854-8725

X. Edward Guo is an expert in bone biomechanics and bioengineering research.
 

Research Interests

µCT, µMRI, and HR-pQCT Image Analysis of Bone Microstructure, Novel Image Based Microstructural and FE Analyses of Osteoporosis and Osteoarthritis Patients, Mechanobiology of 3D In Vitro Trabecular Bone Explants, Mechanotransduction in Osteocyte Network,

Research Areas

Biomechanics

As director of Columbia’s Bone Bioengineering Laboratory, he and his team have two major research thrusts. The first focus of their research is developing innovative three-dimensional imaging and modeling techniques for bone microstructure, such as individual trabecula segmentation and plate-rod finite element modeling methods. These novel techniques have been widely used by engineers and clinicians in studying osteoporosis and other metabolic bone diseases. In addition, these techniques have revealed genetic traits in bone microstructure among various racial groups such as Chinese, Caucasians, and African Americans.  They are currently assembling teams to study genetic variations in various ethnic groups across China and Asia.  More recently, the individual trabecula segmentation technique has discovered early changes in bone microstructure in osteoarthritis, a major disease without therapeutic interventions.

The second line of research of Guo’s group is mechanobiology of the skeleton.  Using innovative single cell, in vitro, ex vivo, and in vivo approaches, they have developed innovative technologies to study cell responses to mechanical Loading and began to reveal the mystery of century old Wolff’s law.

Guo joined Columbia in 1996. He holds a BS in applied mechanics/biomechanics from Peking University, 1984, and received his MS in engineering science from Harvard University in 1990.  He earned his PhD in   medical physics and medical engineering from Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology in 1994, and did post-doctoral training at the University of Michigan.

 

Professional Experience

  • Graduate Research Assistant, Department of Mechanics, Peking University Beijing, P. R. China, 1984-1988
  • Graduate Research Assistant, Department of Mechanical Engineering, The City College of the City University of New York, 1988-1989
  • Graduate Research Assistant, Orthopaedic Biomechanics Laboratory, Harvard University Medical School, 1990-1993
  • Postdoctoral Research Fellow, Orthopaedic Research Laboratories, University of Michigan, 1993-1996
  • Assistant Professor of Mechanical Engineering, Department of Mechanical Engineering, Columbia University, 1996-1998
  • Chair, Graduate Committee, Center for Biomedical Engineering, Columbia University, 1997-1999 
  • Assistant Professor of Biomedical Engineering, Department of Biomedical Engineering, Columbia University, 1998-2001
  • Chair, Undergraduate Committee, Department of Biomedical Engineering, Columbia University, 1999-2003
  • Chair, ABET Committee, Department of Biomedical Engineering, Columbia University, 2004-2006
  • Associate Professor of Biomedical Engineering, (with tenure 2003) Department of Biomedical Engineering, Columbia University, 2001-2007 
  • Associate Professor of Dental and Craniofacial Bioengineering (in Dentistry), College of Dental Medicine, Columbia University, 2004-2007
  • Professor of Biomedical Engineering, Department of Biomedical Engineering, Columbia University, 2007-
  • Chair, Undergraduate Committee, Department of Biomedical Engineering, 2009-2014
  • Vice Chair, Department of Biomedical Engineering, Columbia University, 2014-2017
  • Chair, Department of Biomedical Engineering, Columbia University, 2017-  

 

 

Research Appointments

  • Graduate Research Assistant, Department of Mechanics, Peking University, 1984-1988 
  • Graduate Research Assistant, Department of Mechanical Engineering,  The City College of the City University of New York, 1988-1989
  • Graduate Research Assistant, Orthopaedic Biomechanics Laboratory, Harvard University Medical School, 1990-1993
  • Postdoctoral Research Fellow, Orthopaedic Research Laboratories,  The University of Michigan, 1993-1996
  • Associate in Orthopaedic Research, New York Orthopaedic Hospital Research Laboratory, New York-Presbyterian Hospital, 1996-2001
  • Director, Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, 1997-
  • Visiting Professor, School of Aeronautics and Astronautics, Xian Jiaotong University, Xian, P. R. China, 2008
  • Visiting Professor, the Fourth Military Medical University, Xian, P. R. China, 2012
  • Visiting Professor, Beijing Institute of Technology, Beijing, P. R. China, 2014
  • Visiting Professor, Sichuan University, Chengdu, P. R. China, 2014 

 

Professional Affiliations

  • Member, American Society for Mechanical Engineers
  • Member, American Society for Bone and Mineral Research
  • Member, Orthopaedic Research Society
  • Member, Biomedical Engineering Society

 

Honors & Awards

  • Class Award from the First National Youth Biomedical Engineering Conference of P. R. China., 1985
  • Graduate Fellowship, Division of Applied Sciences, Harvard University, 1989
  • HST Graduate Fellowship, Harvard-MIT Division of Health Science and Technology, 1990
  • The New Investigator Recognition Award, Orthopaedic Research Society, 1992
  • Postdoctoral Trainee of National Institute on Aging, 1994
  • National Research Service Award, National Institutes of Health, 1995
  • Marine Biological Laboratory Summer Course Fellowship, Marine Biological Laboratory, 1997
  • National Science Foundation CAREER Award, 1999
  • Funds for Talented Professionals (Joint Research Fund for Overseas Chinese Young Scholars), National Natural Science Foundation of China, 2006
  • Fellow, American Institute for Medical and Biological Engineering, 2006
  • 1000Plan Professorship, West China School of Stomatology, Sichuan University, 2014
  • Fellow, International Combined Orthopaedic Research Societies, 2016
  • Fellow, International Academy of Medical and Biological Engineering, 2018
  • Fellow, American Society for Mechanical Engineers, 2018

Selected Publications

  • Guo, X. E., and Kim, C. H. (2002) Mechanical Consequence of Trabecular Bone Loss and Its Treatment: A Three-Dimensional Model Stimulation, Bone, 30(2): 404-411.
  • Dong, X. N. and Guo, X. E. (2004) The dependence of transversely isotropic elasticity of human femoral cortical bone on porosity, J. Biomech., 37:1281-2187.
  • Liu, X. S., Sajda, P., Saha, P. K., Wehrli, F. W., Bevil, G., Keaveny, T. M., and Guo, X. E. (2008) Complete Volumetric Decomposition of Individual Trabecular Plates and Rods and Its Morphological Correlations with Anisotropic Elastic Moduli in Human Trabecular Bone, Journal of Bone Mineral Research, 23(2):223-235.
  • Liu, X.S., Walker M.D., McMahon, D.J., Udesky, J., Liu, G., Bilezikian, J.P., and Guo, X. E. (2011) Better skeletal microstructure confers greater mechanical advantages in Chinese-American women versus white women, Journal of Bone and Mineral Research, 26(8):1783-1792.
  • Liu, X. S., Stein, E. M., Nickolas, T. L., Cohen, A., Thomas, V., McMahon, D. J., Zhang, C., Zhou, B., Cosman, F., Nieves, J., Shane, E. and Guo, X. E. (2012) Individual Trabeculae Segmentation (ITS)-Based Morphological Analyses of High-Resolution Peripheral Quantitative Computed Tomography Images Discriminate Fracture Status in Post-menopausal Women Independent of BMD, Journal of Bone and Mineral Research, 27(2): 263-272.
  • Lu, X. L., Huo B., Chiang, V. C., Baik, A. D., and Guo, X. E. (2012) Osteocytic Network Is More Responsive in Calcium Signaling than Osteoblastic Network under Fluid Flow, Journal of Bone and Mineral Research, 27(3): 563-574.
  • Jing, D., Baik, A. D., Lu, X. L., Zhou, B., Lai, X., Wang, L. Luo, E., and Guo, X. E. (2014) In Situ Intracellular Calcium Oscillations in Osteocytes in Intact Mouse Long Bones under Dynamic Mechanical Loading, FASEB Journal, 28(4):1582-1592.
  • Wang, J., Zhou, B., Liu, X. S., Fields, A. J., Sanyal, A., Shi, X., Adams, M., Keaveny, T. M., and Guo, X. E. (2015) Trabecular Plates and Rods Determine Elastic Modulus and Yield Strength of Human Trabecular Bone, Bone, 72(3):71–80.
  • Chen, Y., Hu, Y., Yu, Y. E., Zhang, X., Watts, T., Zhou, B., Wang, J., Wang, T., Zhao, W., Chiu, K. Y., Leung, F., K., L., Cao, X., Macaulay, W., Nishiyama, K. K., Shane, E., Lu, W. W., and Guo, X. E. (2018) Subchondral Trabecular Rod Loss and Plate Thickening in the Development of Osteoarthritis, Journal of Bone and Mineral Research, 33(2):316-327.
  • Morrell, A. E., Brown, G. N., Robinson, S. T., Sattler, R. L., Baik, A. D., Zhen, G., Cao, X., Bonewald, L. F., Jin, W., Kam, L. C., and Guo, X. E. (2018) Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation, Bone Research, 6:6.