Christine P. Hendon
ASSOCIATE PROFESSOR OF ELECTRICAL ENGINEERING
CEPSR 805
Mail Code 4712
Christine P. Hendon develops biomedical optics technologies for biomedicine to guide interventional procedures and to provide insights into the structure-function relationship of biological normal, diseased, and treated tissues. She has worked on developing next-generation optical coherence tomography systems and integrated therapeutic catheters with near infrared spectroscopy, along with real-time processing algorithms to extract physiological information. Hendon collaborates extensively with investigators from Columbia University School of Engineering and Applied Science and the Medical Center. Her group has developed integrative optics and therapeutic probes for improving the treatment of cardiac arrhythmias.
Research Interests
Optical coherence tomography, near infrared spectroscopy, cardiac electrophysiology, oncology, image processingOf particular interest to Hendon is the use of optical imaging modalities for improving therapeutic procedures. The research goals of the Structure-Function Imaging Laboratory are to develop platform optical imaging systems to enable structure-function analysis of biological organ systems. Towards this goal, the Lab develops optical coherence tomography (OCT) and near infrared spectroscopy (NIRS) systems and automated processing tools to correlate tissue microstructure to electrical conduction and mechanical contraction. The main clinical driver within this work is addressing unmet needs in cardiac electrophysiology. Hendon works closely with cardiac electrophysiologist, pathologist, and other engineers as they strive to develop catheters and algorithms that will enable improved guidance and monitoring of arrhythmia therapy.
Hendon received a BS in electrical engineering and computer science from the Massachusetts Institute of Technology in 2004 and a PhD in biomedical engineering from Case Western Reserve University, in 2010. She was awarded the Presidential Early Career Award for Scientists and Engineers (PECASE) in 2017.
RESEARCH EXPERIENCE
- Postdoctoral fellow, Harvard Medical School, 2010-2012
PROFESSIONAL EXPERIENCE
- Assistant professor of electrical engineering, Columbia University, 2012–present
PROFESSIONAL AFFILIATIONS
- National Society of Black Engineers (NSBE)
- The International Society for Optics and Photonics (SPIE)
- The Optical Society (OSA)
HONORS & AWARDS
- Presidential Early Career Awards for Scientists and Engineers (PECASE), 2017
- Rodriguez Family Junior Faculty Development Award, Columbia University SEAS, 2015
- NSF CAREER Award, 2015
- NIH DP2 New Innovators, 2014
- MIT Technology Review: 35 Innovators under 35, 2013
- Forbes 30 under 30 for Science and Healthcare, 2012
SELECTED PUBLICATIONS
- Yuye Ling, Yu Gan, Xinwen Yao, and Christine P Hendon. Phase noise analysis on swept-source optical coherence tomography system. Optics Letters. 42(7) 1333-1336. (2017)
- Yuye Ling, Xinwen Yao, Ute T. Gamm, Emilio S. Arteaga-Solis, Charles W. Emala, Michael A. Choma, and Christine P. Hendon. Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography. Lasers in Surgery and Medicine. 49(3) 270–279. (2017) In Press (Selected as Editor’s Choice Paper)
- Xinwen Yao **, Yu Gan **, Ernest Chang, Hanina Hibshoosh, Sheldon Feldman, and Christine P Hendon. Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT. Lasers in Surgery and Medicine. 49(3) 258–269. (2017) ** denotes equal contribution. (Selected as Feature of the Week on octnews.org)
- Nathan C Lin, Christine P Hendon, Elizabeth Olson. Paper. Signal competition in optical coherence tomography and its relevance for cochlear vibrometry. The Journal of the Acoustical Society of America. 141 (1), 395 – 405. (2017)
- Dovina Qu, Philip J Chuang, Sagaw Prateepchinda, Priya Balasubramanian, Xinwen Yao, Stephen Doty, Christine P Hendon, and Helen H Lu. Micro- and Ultrastructural Characterization of Age-Related Changes at the Anterior Cruciate Ligament-to-Bone Insertion. ACS Biomaterials Science & Engineering. (2016) In Press
- Wang Yao **, Yu Gan *,* Kristin Myers, Joy Vink, Ronald Wapner, and Christine P. Hendon. Pregnant and Non-Pregnant Collagen Fiber Orientation and Dispersion of the Upper Cervix. PLOS One. 11(11): e0166709. (2016) ** denotes equal contribution.
- Yu Gan, David Tsay, Syed Bin Amir, Charles C. Marboe, and Christine P. Hendon. Automated classification of optical coherence tomography images of human atrial tissue. Journal of Biomedical Optics. Vol 21 (10), 101407 (2016)
- Xinwen Yao, Yu Gan, Charles C. Marboe, and Christine P. Hendon. Myocardial Imaging using Ultrahigh Resolution Spectral Domain Optical Coherence Tomography. Journal of Biomedical Optics. 21(6), 061006 (2016)
- Rajinder P. Singh-Moon, Charles C. Marboe, and Christine P. Hendon. A near-infrared spectroscopy integrated catheter for characterization of myocardial tissues: preliminary demonstrations to radiofrequency ablation therapy for atrial fibrillation. Biomedical Optics Express. Vol 6(7) pp. 2494-2511 (2015)
- Kristin M Myers, Christine P Hendon, Yu Gan, Wang Yao, Joy Vink, and Ronald Wapner. A continuous Fiber Distribution Material Model for Human Cervical Tissue. Journal of Biomechanics. 48(9) pp. 1533-1540 (2015).
- Yu Gan, Wang Yao, Kristin M Myers, Joy Y Vink, Ronald J Wapner, and Christine P Hendon. Analyzing three-dimensional ultrastructure of human cervical tissue using optical coherence tomography. Biomedical Optics Express. 6(4) pp. 1090-1108 (2015).
- Yu Gan and Christine P Fleming. Three-dimensional quantification and tractography of fibers in myocardial tissues using optical coherence tomography. Biomedical Optics Express. 4(10) pp. 2150-2165 (2013)