Aaron Moment

PROFESSOR OF PRACTICE IN CHEMICAL ENGINEERING

803 S.W. Mudd
Mail Code 4721

Tel(212) 853-1829

Aaron Moment researches methodologies for developing manufacturing processes for fine chemical, pharmaceutical and biopharmaceutical products. By applying advances in sensing, imaging, visualization, modeling, simulation, and materials, Aaron devises more robust, reliable, efficient, safer, portable processes that are less sensitive to scale-up challenges and disruptions.

Prior to joining Columbia, Moment spent 16 years in the pharmaceutical industry as a chemical engineer at Merck & Co. and DuPont Pharmaceuticals, where he developed expertise in reaction engineering, crystallization design, process scale-up, technology transfer, quality by design, process characterization, process definition, process safety, process analytical technology, and particle engineering.  He holds a BS in Chemical Engineering from Rensselaer Polytechnic Institute, and MS and PhD degrees in Chemical Engineering from MIT.  He was a member of the 2006 and 2010 USPA Presidential Green Chemistry award teams for improvements to manufacturing Sitagliptin (Januvia), and is author of 5 patents related to pharmaceutical processes. He is a member of American Institute of Chemical Engineers (AIChE) and the American Chemical Society (ACS).

SELECTED PUBLICATIONS

  • Zhou, G., Grosser, S., Sun, L., Graffius, G., Prasad, G., Moment, A., Spartalis, A., Fernandez, P., Higgins, J., Wabulye, B., Starbuck, C., "Application of On-Line NIR for Process Control during the manufacture of Sitagliptin" Organic Process Research & Development, 20(3), 653-660 (2016).
  • Zhou, G., Moment, A., Yuang, S., Cote, A., Hu, Tseng-En, "Evolution and Application of and Automated Platform for the Development of Crystallization Processes," Organic Process Research & Development, 17(10), 1320-1329 (2013).
  • Zang, Jia, Sirota, E., Moment, A., Williams, M., Tellers, D., Helmy, R., "Development and Application of a User-Friendly Automated HPLC Dilution Macro for API Route Optimization," Organic Process Research & Development, 16(2), 250-254 (2012).
  • Cote, A., Sirota, E., Moment, A., "The pursuit of a robust approach for growing crystals directly to target size," American Pharmaceutical Review, p. 31-35 (Nov/Dec 2010).
  • Zhou, G., Moment, A., Cote., A., Hu, T.E., "Utilizing spectroscopy for the isolation of desired API crystal form," American Pharmaceutical Review, 12(5), 62-68 (2009).
  • M. Hickey, S. Allwein, T. Nelson, M. Kress, O. Sudah, A. Moment, S. Rodgers, M. Kaba, P. Fernandez, “Process Development and Pilot Plant Synthesis of Methyl-2-Bromo-6-Chlorobenzoate,” Organic Process Research and Development, 9, 764-767 (2005).
  • A. Moment and P.T. Hammond, "Block Copolymers of Polystyrene and Side-Chain Liquid Crystalline Siloxanes: Morphology and Thermal Properties," Polymer, 42, 6945-6959 (2001)
  • A. Moment, R. Miranda and P.T. Hammond, "Synthesis of Polystyrene-Polysiloxane Side-Chain Liquid Crystalline Block Copolymers", Macromol. Rapid Commun., 19, 573-579 (1998).
  • Nair, W.Y. Zheng, A. Moment, and P.T. Hammond, "Diblock and Multiblock Liquid Crystalline Polymeric Systems", American Chemical Society Polymer Preprints, 38, No. 1, 416 (1997).